Short Curriciulum of Research

Dr Ewa Rajpert-De Meyts

Affiliation

Copenhagen University Hospital (Rigshospitalet)
Department of Growth & Reproduction
Contact: erm(at)rh.dk

Research Activities

My main research interest is in development of human gonads and pathogenesis of germ cell disorders, with focus on premalignant lesions, which are associated with gonadal dysgenesis and DSD. The aim of the ongoing studies is to understand why the incidence of germ cells cancer and male infertility have been increasing and to identify possible environmental factors as well as early markers of germ cell transformation.

Education/ Training

1980MD, Silesian Medical University, Katowice, Poland
1984PhD (Dr. med.), Silesian Medical University, Katowice, Poland
2006DMSc (Dr. med.), Copenhagen University, Faculty of Health Sciencies, Denmark

Research Experience/ Academic Appointments

1980-1985Academic Assistant, 1st Paediatric Hospital of the Silesian Medical University, Zabrze, Poland
1985-1986Exchange Fellow of the Belgian French-speaking Community, Hormone & Metabolism Research Unit, International Institute of Cellular and Molecular Pathology (currently De Duve Institute), Brussels, Belgium
1986-1990Research Fellow in the Molecular Genetics Section, Division of Medical Genetics, Children's Hospital, Los Angeles, California, USA
1990- cont.Research Fellow, from 1999 Senior Scientist and Research Group Leader (Forskningsleder), Department

 

Important Scientific Prizes/ Functions

2003Roger Cotton Histopathology Award (for the best paper published in 2002)
2005ESPE Hennig Andersen Award for best basic abstract: Expression of NANOG in normal and dysgenetic testis development (senior author on the paper presented by the first author C. Hoei-Hansen)
2007 Benchmark lecture: Developmental Model of Testicular Cancer, at the American Testis Workshop and American Society of Andrology Joint Meeting, Tampa, FL, USA
2009-2012Editor-in-Chief of International Journal of Andrology
2012-cont.Co-Editor-in-Chief of Andrology

Publications

5 main publications with relevance to DSDnet (last 5 years)

  • Sonne SB, Almstrup K, Dalgaard M, Juncker AS, Edsgard D, Ruban L, Harrison NJ, Schwager C, Abdollahi A, Huber PE, Brunak S, Gjerdrum LM, Moore H, Andrews PW, Skakkebæk NE, Rajpert-De Meyts E, Leffers H. Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte. Cancer Res 2009; 69: 5241-5250.
  • Almstrup K, Nielsen JE, Mlynarska O, Jansen MT, Jørgensen A, Skakkebæk NE, Rajpert-De Meyts E. Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells. Br J Cancer 2010, 103: 1269-1276.
  • Lindhardt Johansen M, Hagen CP, Rajpert-De Meyts E, Kjærgaard S, Petersen BL, Skakkebæk NE, Main KM, Juul A. 45,X/46,XY mosaicism: Phenotypic characteristics, growth and reproductive function – a retrospective longitudinal study. J Clin Endocrinol Metab 2012, 97: E1540-1549.
  • Jørgensen A, Nielsen JE, Almstrup K, Toft BG, Petersen BL, Rajpert-De Meyts E. Dysregulation of the mitosis-meiosis switch in testicular carcinoma in situ. J Pathol 2013; 229: 588-598.  
  • Lottrup G, Nielsen JE, Maroun LL, Møller LMA, Yassin M, Leffers H, Skakkebæk NE, Rajpert-De Meyts E. Expression patterns of DLK1 and INSL3 identify stages of Leydig cell differentiation during normal development and in testicular pathologies, including testicular cancer and Klinefelter syndrome. Hum Reprod 2014; 29: 1637-1650.