Short Curriculum of Research

Dr Andy Greenfield

Affiliation

Medicla Research Council
Mammalian Genetics Unit
Contact: a.greenfield(at)har.mrc.ac.uk

Education/ Training

1981-1984University of Cambridge – BA (Natural Sciences)
1984-1988Imperial College, University of London – PhD (Mouse Molecular Genetics)

Research Experience/ Academic Appointments

1988-1992St. Mary’s Hospital Medical School, University of London - Postdoctoral Researcher
1992-1996Institute for Molecular Biosciences, Queensland, Australia – Postdoctoral Researcher (Mouse Y Chromosome and Sex Determination)
1996- presentMRC Harwell – Programme Leader in Mammalian Sexual Development

Important Scientific Prizes/ Functions

2003-2007;
2009-2010
Member of the Wellcome Trust’s Molecules, Genes & Cells Funding Committee
2012-presentMember of Wellcome Trust’s Biomedical Resource & Multi-User Equipment Themed Strategic Award Committee
2009-presentMember of the UK Human Fertilisation & Embryology Authority (HFEA); Chair of License Committee (since 2014)
2014-presentMember of the Nuffield Council on Bioethics

Publications

5 main publications with relevance to DSDnet (last 5 years)

  • Bogani et al. (2009) Loss of Mitogen-activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination. PLoS Biol 7(9):e1000196
  • Pearlman et al. (2010) Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination. Am.J.Hum.Genet 87:898-904
  • Warr et al. (2011) Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signaling component, MAP3K1. PLoS ONE 6(5): e19572
  • Warr et al. (2012) Gadd45g and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression. Dev. Cell 23: 1020-1031
  • Warr et al. (2014) Transgenic overexpression of Map3k4 rescues T-associated sex reversal (Tas) in mice. Hum. Mol. Genet. 23: 3035-3044