Short Curriculum of Research

Prof Leendert H. J. Looijenga (3rd)

Affiliation

Erasmus Medical Center Rotterdam
Josephine Nefkens
Pathology
Contact: l.looijenga(at)erasmusmc.nl

Education/ Training

1984-1989Biology, University of Groningen (the Netherlands), Medical Cell Biology

Research Experience/ Academic Appointments

1989-1990Visiting Scientist Leiden University (the Netherlands)
1999Assistant Prof. Pathology, Erasmus University, Rotterdam (the Netherlands)
2005Prof. Translational Patho-Oncology, Erasmus University Medical Center

Important Scientific Prizes/ Functions

2011Emil Steinberger Award (ASA)

Publications

5 main publications with relevance to DSDnet (last 5 years)

  • Hersmus R, Van der Zwan Y, Stoop, H, Barnard P, Sreenivasan R, Oosterhuis JW, Bruggenwirth HT,  De Boer S, White S, Wolffenbuttel KP, Alders M, McElreavy, Drop SLS, Harley VR, Looijenga LHJ. A 46,XY Female DSD Patient with Bilateral Gonadoblastoma, a Novel SRY Missense Mutation Combined with a WT1 KTS Splice-Site Mutation. PLoS One. 2012; 7(7): e40858. Epub 2012 Jul 18.
  • Hersmus R, Stoop H, Van de Geijn GJ, Biermann K, Oosterhuis JW, DHooge C, Schneider DT, Meijssen IC,  Dinjens WNM, Dubbink HJ, Drop SLS, Looijenga LHJ.  Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with Disorders of Sex Development (DSD) and ovarian dysgerminomas. PLoS One. 2012;7(8):e43952: Epub 2012 Aug. 28.
  • Hersmus R, Stoop H, Turbitt E, Oosterhuis JW, Drop SLS, Sinclair AH, White S,  Looijenga.SRY mutation analysis by next generation (deep) sequencing in a cohort of chromosomal Disorders of Sex Development (DSD) patients with a mosaic karyotype. BMC Med Genet. 2012: 13:108.
  • Kaprova-Pleskacova J, Snajderova M, Stoop J, Koudova M, Kocarek E, Novotna D, Drop SLS, Obermannova B,  Lebl J, Oosterhuis JW, Looijenga LHJ. 45,X/46,X,psu dic(Y) gonadal dysgenesis: Influence of the two cell lineages on the clinical phenotype, including gonadal histology. Sex. Developm. 2013; 7: 282-288.
  • Kaprova-Pleskacova J, Stoop H, Bruggenwirth H, Cools M, Wolffenbuttel KP, Drop SLS, Snajderova M, Lebl J, Oosterhuis JW, Looijenga LHJ. Complete androgen insensitivity syndrome: factors influencing gonadal histology including germ cell pathology. Mod. Pathol. 2013; Nov. in press.