Short Curriculum of Research
Prof Martine Cools
Ghent University and Ghent University Hospital
The research activities of our group focus on genetic causes of DSD, gonadal differentiation patterns, risk for germ cell cancer and on long-term psychosexual outcome. We are interested in receiving gonadectomy material and DNA samples of DSD cases for research purposes (including whole exome sequencing)
|2006||Clinical Fellowship Pediatric Endocrinology, Rotterdam, The Netherlands. Supervision: Sten Drop|
|2004-2005||Research Fellowship, Rotterdam, The Netherlands. Supervision: Leendert Looijenga|
|1998-2003||Pediatrics, Antwerp, Belgium|
Research Experience/ Academic Appointments
|Since 2011||Head of the Department of Pediatric and Adolescent Endocrinology and Diabetology, University Hospital Ghent, Belgium|
|Since 2010||Associate Professor of Pediatric Endocrinology at the Faculty of Medicine, Department of Pediatrics, University of Ghent, Belgium|
|Since 2008||Coordinator of the Disorders of Sex Development (DSD) subgroup of the Belgian Society for Pediatric Endocrinology|
|Since 2007||Senior staff member at the Service of Pediatric and Adolescent Endocrinology and Diabetology, Department of Pediatrics, University Hospital Ghent, Belgium|
|Since 2007||Coordinator of the multidisciplinary team for patients with Disorders of Sex Development at the University Hospital Ghent|
|Since 2007||Member of the multidisciplinary team for children and adolescents with Gender Identity Disorder|
|PhD Thesis 2006||Germ cell tumors in patients with disorders of sex development: Risk factors, initial developmental stages and targets for early diagnosis. Martine Cools. PhD Thesis, 2006. ISBN: 905677106X.|
Important Scientific Prizes/ Functions
|2010||ESPE Young Investigator Award|
|Since 2007||Senior Clinical Investigator at the University of Ghent, Belgium, granted by the Research Foundation Flanders (FWO)|
5 main publications with relevance to DSDnet (last 5 years)
- Integrated clinical, hormonal and genetic screening in a consecutive series of 32 undervirilized 46,XY neonates and infants. D Baetens, V Mladenov, B Delle Chiaie, B Menten, A Desloovere, V Iotova, B Callewaert, E Van Laecke, P Hoebeke, E De Baere and M Cools. Orphanet Journal of Rare Diseases 2014. E-pub ahead of print.
- Novel insights in gonadal development as risk factor for germ cell cancer: Towards a clinical decision model. YG van der Zwan, K Biermann, KP Wolffenbuttel, M Cools and LHJ Looijenga. 2014 Eur Urol. 2014 Sep 17. pii: S0302-2838(14)00651-4. doi: 10.1016.
- An update on surgical and non-surgical treatments for vaginal hypoplasia. N Callens, G De Cuypere, P De Sutter, S Monstrey, S Weyers, P Hoebeke and M Cools. Human Reproduction Update 2014, 2014 Sep-Oct;20(5):775-801. Doi: 10.1093/humupd/dmu024.
- Vaginal dilation treatment in women with vaginal hypoplasia: A prospective long term intervention study. N Callens, S Weyers, S Monstrey, S Stockman, B Van Hoorde, E Van Hoecke, G De Cuypere, P Hoebeke and M Cools. Am J Obstet & Gynecol, accepted.
- Gonadal pathology and tumor risk in relation to clinical characteristics in patients with 45,X/46,XY mosaicism. M Cools, J Pleskacova, H Stoop, P Hoebeke, E Van Laecke, SLS Drop, J Lebl, JW Oosterhuis, LHJ Looijenga, KP Wolffenbuttel, on behalf of the Mosaicism Collaborative Group. Journal of Clinical Endocrinology and Metabolism, 2011; Jul 96(7): E1171-E1180.