Short Curriculum of Research

Hedi Claahsen - van der Grinten

Affiliation

Radoud University Medical centre
Department of Pediatric Endocrinology
Contact: hedi.claahsen(at)radboudumc.nl

Research Activities

My research group focuses on adrenal diseases with a special interest in  clinical and translational studies  on defects in adrenal steroidsynthesis defects (congenital adrenal hyperplasia (CAH)) and disorders of sexual differentiation (DSD).

Main themes: Aetiology and functional features of testicular adrenal rest tumours in CAH, cardiovascular risk profile in pediatric CAH, Functional features and clinical consequences of adrenal steroid precursors, EU DSD life study

Education/ Training

2007PhD diploma: Adrenal rest tumours in congenital adrenal hyperplasia
2006Registrations as Pediatric Endocrinologist
2002–2006Training in Pediatric Endocrinology at the Department of Pediatric Endocrinology of the Radboud University Nijmegen Medical Centre, The Netherlands.
2002Registration as pediatrician
1996–2002Pediatric training at the Radboud University Nijmegen Medical Centre, The Netherlands
1989–1996University Medical School of the Radboud University Nijmegen, the Netherlands (doctoral exam cum laude)

Research Experience/ Academic Appointments

Since 2014Head of the department of pediatric endocrinology Radboud University Medical Centre , Nijmegen
Since 2014Principal clinician Rdboud University Nijmegen
Since 2013Coordinator Radboud DSD centre (expert centre for disorders of sexual differentiation)
Since 2010Chair of the national congenital adrenal hyperplasia working group
Since 2010Member of the national working group neonatal screening program of the national institute of public health and environment (RIVM)
Since 2010Founding member and member of the steering commite of the Radboud Adrenal Centre
Since 2008Medical advisor Dutch patient organisations adrenal diseases (NVACP) and DSD (DSD NL)
2003–2010Secretary of the national congenital adrenal hyperplasia working group
Since 2002Staff member at the department of Pediatric Endocrinology at the Radboud University Nijmegen Medical Centre, The Netherlands

Publications

  • Inactivating PAPSS2 mutations in a patient with premature pubarche. Noordam C, Dhir V, McNelis JC, Schlereth F, Hanley NA, Krone N, Smeitink JA, Smeets R, Sweep FC, Claahsen-van der Grinten HL, Arlt W. N Engl J Med. 2009 360(22):2310-8.
  • Congenital adrenal hyperplasia - Pharmacologic interventions from the prenatal phase to adulthood. Claahsen – van der Grinten HL, Stikkelbroeck NM, Otten BJ, Hermus AR. Pharmacol Ther. 2011;132:1-14
  • Adrenal function: A gold standard test for adrenal insufficiency in children? Claahsen-van der Grinten HL, Otten BJ.  Nat Rev Endocrinol 2010, 6:605-6
  • Molecular Characterization of Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia; Lesions with both Adrenocortical and Leydig Cell Features. Evelien E.J.W. Smeets, Paul N. Span, Antonius E. van Herwaarden, Ron A. Wevers, Fred C.G.J. Sweep, Hedi L. Claahsen-van der Grinten; J Clin Endocrinol Metab 2014: epub ahead to print